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Updated: Jun 5, 2026
12:04
Mouse Genome Engineering Using Designer Nucleases
Published on: April 2, 2014
Genetic engineering: Processes and products
1Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France.
Trends in Ecology & Evolution
|January 14, 2011
Abstract:
Most genetically engineered organisms have travelled no further than the walls or filters of containment laboratories and fermentors. The basic techniques used to produce these organisms are much the same as those used to engineer strains which are to be released into the environment. An examination of the fundamentals of genetic engineering as applied in the production of high-value pharmaceuticals illustrates the capability and limitations of current methods.
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...