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Related Experiment Video

Updated: Jun 5, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

Extracorporeal life support systems: alternative vs. conventional circuits.

Sameer Khan¹, Rahul Vasavada, Feng Qiu

¹Pediatric Cardiovascular Research Center, and Department of Pediatrics, Milton S. Hershey Medical Center, Penn State Hershey College of Medicine, 500 University Drive, Hershey, PA 17033, USA.

|January 14, 2011

Summary

This study compared pediatric extracorporeal life support (ECLS) circuits, finding the Quadrox-iD oxygenator with a centrifugal pump offers lower pressure drops and better hemodynamic energy retention. This alternative circuit also boasts faster setup and transport for pediatric ECLS.

Related Experiment Videos

Last Updated: Jun 5, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

Area of Science:

Biomedical Engineering
Pediatric Critical Care Medicine

Background:

Extracorporeal life support (ECLS) technologies for pediatric and neonatal patients are rapidly advancing.
Optimizing circuit performance is crucial for improving patient outcomes in ECLS.

Purpose of the Study:

To compare the performance of the Medtronic 0800 and Quadrox-iD Pediatric oxygenators in a conventional roller pump circuit.
To evaluate an alternative circuit using the Quadrox-iD Pediatric oxygenator with a Maquet Rotaflow centrifugal pump system.

Main Methods:

Three ECLS circuits were tested: two conventional roller pump circuits (Medtronic 0800 vs. Quadrox-iD) and one alternative centrifugal pump circuit (Quadrox-iD with Maquet Rotaflow).
Circuits were primed with blood (40% hematocrit) and Lactated Ringer's solution.
Testing was conducted at various flow rates (250-750 ml/min) and mean arterial line pressures (60-100 mmHg) at 37°C.

Main Results:

The Quadrox-iD Pediatric oxygenator demonstrated lower pressure drops and greater retention of total hemodynamic energy (THE) compared to the Medtronic 0800.
The centrifugal pump in the alternative circuit showed no backflow at 250 ml/min and maintained low RPMs (below 2200) up to 750 ml/min.
The alternative circuit exhibited advantages such as rapid setup, portability, reduced priming volumes, and non-gravity-dependent venous drainage.

Conclusions:

The Quadrox-iD Pediatric oxygenator is recommended for use with the Maquet Rotaflow centrifugal pump system in pediatric ECLS.
This alternative circuit configuration offers superior hemodynamic performance and practical benefits for clinical application.