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Updated: Jun 5, 2026
09:53
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
Skull base presentation of multiple myeloma
Anil Joshi1, Dan Jiang, Pranay Singh
1Neurotology and Skull Base Surgery Unit, Department of Otolaryngology, Addenbrooke's Hospital, Cambridge, UK. aniljoshient@yahoo.com
Ear, Nose, & Throat Journal
|January 14, 2011
Summary
Multiple myeloma, a plasma cell disorder, can manifest in the skull base, a rare presentation. This case highlights the importance of considering this malignancy even with unusual symptoms like disequilibrium.
Area of Science:
- Hematology
- Oncology
- Neurology
Background:
- Plasma cell disorders range from benign plasmacytomas to malignant multiple myeloma.
- Multiple myeloma typically presents with systemic symptoms, making skull base involvement rare.
Observation:
- A 66-year-old man presented with a 2-year history of disequilibrium.
- Extensive skull base involvement by multiple myeloma was diagnosed.
Findings:
- Multiple myeloma can present with localized symptoms when affecting the skull base.
- This rare presentation challenges typical diagnostic criteria for multiple myeloma.
Implications:
- Highlights the need to consider multiple myeloma in rare skull base lesions.
- Emphasizes the diverse clinical manifestations of plasma cell neoplasms.
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