Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Postsynaptic Potential (PSP)01:32

Postsynaptic Potential (PSP)

Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
Neural Circuits01:25

Neural Circuits

Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Integration of Synaptic Events01:28

Integration of Synaptic Events

Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Sema3A Interference on Cerebellum-Dependent Motor Associative Learning and Memory.

International journal of molecular sciences·2026
Same author

Emotional and attentional anomalies underlying triarchic psychopathic traits: an EEG-startle blink study.

BMC psychology·2026
Same author

Neurobehavioral Assessment of Sensorimotor Function in Autism Using Smartphone Technology.

Autism research : official journal of the International Society for Autism Research·2026
Same author

Neurobiological mechanisms underlying the beneficial effects of music interventions in perioperative care: a narrative review.

Acta psychologica·2025
Same author

Aberrant neural activity in the peritumoral cortex underlies the progression of tumor-associated seizures.

Nature communications·2025
Same author

Duration of music listening in music-induced analgesia: A pilot randomized controlled trial.

Complementary therapies in medicine·2025

Related Experiment Video

Updated: Jun 5, 2026

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
09:30

Assessment of Long-term Depression Induction in Adult Cerebellar Slices

Published on: October 16, 2019

Presynaptic plasticity at cerebellar parallel fiber terminals.

M-C Le Guen1, Chris I De Zeeuw

  • 1Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.

Functional Neurology
|January 15, 2011
PubMed
Summary

This study highlights presynaptic plasticity in the cerebellum

Area of Science:

  • Neuroscience
  • Cellular and Molecular Neuroscience

Background:

  • The cerebellum is crucial for sensorimotor control and cognitive functions.
  • Granule cells in the cerebellum facilitate sparse coding and high afferent sensitivity.
  • Plasticity in the granular layer supports input transformation and procedural memory.

Purpose of the Study:

  • To review granular layer processing models in the cerebellum.
  • To emphasize presynaptic modulations at the parallel fiber to Purkinje cell synapse.
  • To explore the role of presynaptic plasticity in cerebellar learning and memory.

Main Methods:

  • Review of existing literature on cerebellar granular layer processing.
  • Analysis of models focusing on presynaptic plasticity mechanisms.
  • Framework analysis of cerebellar functioning and computational capacities.

More Related Videos

Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development
04:20

Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development

Published on: June 9, 2021

Presynaptically Silent Synapses Studied with Light Microscopy
11:02

Presynaptically Silent Synapses Studied with Light Microscopy

Published on: January 4, 2010

Related Experiment Videos

Last Updated: Jun 5, 2026

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
09:30

Assessment of Long-term Depression Induction in Adult Cerebellar Slices

Published on: October 16, 2019

Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development
04:20

Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development

Published on: June 9, 2021

Presynaptically Silent Synapses Studied with Light Microscopy
11:02

Presynaptically Silent Synapses Studied with Light Microscopy

Published on: January 4, 2010

Main Results:

  • Presynaptic plasticity at the parallel fiber to Purkinje cell synapse has been underexplored.
  • A wide range of presynaptic mechanisms can strengthen this synapse.
  • These mechanisms enhance the cerebellum's computational capacity for memory formation.

Conclusions:

  • Presynaptic plasticity is vital for cerebellar functions, particularly memory.
  • The cerebellum's computational power is optimized by presynaptic mechanisms.
  • Further research into presynaptic plasticity is essential for understanding cerebellar learning.