Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Regulation of Heart Rates01:31

Regulation of Heart Rates

The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Sustained Joint Loading on TMJ Disc Nutrient Environment.

Journal of dental research·2019
Same author

Correction: Overexpression of miR-489 derails mammary hierarchy structure and inhibits HER2/neu-induced tumorigenesis.

Oncogene·2018
Same author

Overexpression of miR-489 derails mammary hierarchy structure and inhibits HER2/neu-induced tumorigenesis.

Oncogene·2018
Same author

The effects of oxygen level and glucose concentration on the metabolism of porcine TMJ disc cells.

Osteoarthritis and cartilage·2015
Same author

Viscoelastic shear properties of porcine temporomandibular joint disc.

Orthodontics & craniofacial research·2015
Same author

Regional cell density distribution and oxygen consumption rates in porcine TMJ discs: an explant study.

Osteoarthritis and cartilage·2011
Same journal

Comment on "Advancing Personalised Care in Atrial Fibrillation and Stroke: The Potential Impact of AI from Prevention to Rehabilitation".

Trends in cardiovascular medicine·2026
Same journal

Response to: Comment on "Advancing personalised care in atrial fibrillation and stroke: The potential impact of AI from prevention to rehabilitation" (TCM-D-26-00198).

Trends in cardiovascular medicine·2026
Same journal

High-sensitivity C-reactive protein as a prognostic biomarker in cardiovascular diseases: implications for atherosclerosis, chronic kidney disease, and heart failure - a review.

Trends in cardiovascular medicine·2026
Same journal

The cost of false dichotomies in a dynamic disease.

Trends in cardiovascular medicine·2026
Same journal

Late-presenting ST-segment elevation myocardial infarction: is it just a matter of time? From temporal cutoffs to biological staging.

Trends in cardiovascular medicine·2026
Same journal

Targeting rotors in ventricular fibrillation: Molecular mechanisms and future therapeutic strategies.

Trends in cardiovascular medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

High Efficiency Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes and Characterization by Flow Cytometry
13:13

High Efficiency Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes and Characterization by Flow Cytometry

Published on: September 23, 2014

Homeobox genes and heart development.

M J Kern1, E A Argao, S S Potter

  • 1Michael J. Kern, Eric A. Argao, and S. Steven Potter are at the Division of Basic Science Research, Children's Hospital Research Foundation, Cincinnati, OH 45229-3039 USA.; the University of Cincinnati College of Medicine, Cincinnati, OH 45267-0524, USA.

Trends in Cardiovascular Medicine
|January 15, 2011
PubMed
Summary
This summary is machine-generated.

Transcription factor genes, particularly homeobox genes, are crucial genetic switches controlling heart development. Understanding this genetic circuitry aids in identifying and potentially treating inherited cardiac diseases.

More Related Videos

Isolation and Characterization of Single Cells from Zebrafish Embryos
09:25

Isolation and Characterization of Single Cells from Zebrafish Embryos

Published on: March 12, 2016

In Vitro Generation of Heart Field-specific Cardiac Progenitor Cells
09:29

In Vitro Generation of Heart Field-specific Cardiac Progenitor Cells

Published on: July 3, 2019

Related Experiment Videos

Last Updated: Jun 5, 2026

High Efficiency Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes and Characterization by Flow Cytometry
13:13

High Efficiency Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes and Characterization by Flow Cytometry

Published on: September 23, 2014

Isolation and Characterization of Single Cells from Zebrafish Embryos
09:25

Isolation and Characterization of Single Cells from Zebrafish Embryos

Published on: March 12, 2016

In Vitro Generation of Heart Field-specific Cardiac Progenitor Cells
09:29

In Vitro Generation of Heart Field-specific Cardiac Progenitor Cells

Published on: July 3, 2019

Area of Science:

  • Developmental Biology
  • Genetics
  • Cardiology

Background:

  • Transcription factors are DNA-binding proteins that regulate gene expression.
  • These factors act as genetic switches, controlling cellular development and differentiation.
  • Homeobox genes are a critical class of transcription factors implicated in embryonic development.

Purpose of the Study:

  • To investigate the role of transcription factor genes in heart development (cardiogenesis).
  • To elucidate the genetic circuitry governing the formation of the heart.
  • To explore the implications of this research for inherited cardiac diseases.

Main Methods:

  • Expression studies in model organisms.
  • Mutational analyses in mice and Drosophila.
  • Analysis of genetic regulatory networks.

Main Results:

  • Homeobox genes play an essential role in heart development.
  • Specific transcription factors act as key regulators in cardiogenesis.
  • Evidence suggests a conserved function of these genes across species.

Conclusions:

  • Understanding the genetic basis of cardiogenesis is vital for diagnosing and managing inherited cardiac conditions.
  • This knowledge can inform therapeutic strategies, including drug therapy, lifestyle modifications, and gene therapy.
  • Further research into cardiac genetic circuitry can improve genetic counseling and treatment outcomes.