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Updated: Jun 5, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
Molecular and cellular biology of osteopontin Potential role in cardiovascular disease
C M Giachelli1, S M Schwartz, L Liaw
1Cecilia M. Giachelli and Stephen M. Schwartz are at the Department of Pathology SJ-60, University of Washington School of Medicine, Seattle, WA 98195, USA.
Abstract:
Molecular biology has greatly enhanced our ability to identify molecules expressed as a part of the vascular response to injury. Among these, osteopontin is of particular interest. Osteopontin is a multifunctional adhesive glycoprotein implicated in the pathogenesis of a growing number of cardiovascular lesions, including restenosis, atherosclerosis, aortic valve calcification, and repair of myocardial wounds. In this review, we focus on structural, functional, and regulatory properties of osteopontin, which might be particularly relevant to cardiovascular lesion development.
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