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Related Concept Videos

Transgenic Organisms00:53

Transgenic Organisms

Overview
Transgenic Organisms00:53

Transgenic Organisms

Overview
Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
Transgenic Plants02:50

Transgenic Plants

Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...

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Related Experiment Video

Updated: Jun 5, 2026

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness
06:21

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness

Published on: May 7, 2018

Conditional transgenics.

G I Fishman

    Trends in Cardiovascular Medicine
    |January 15, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Conditional transgenics allow precise control over gene expression in mice. This technology enhances the study of gene function and cardiovascular disease models by enabling regulated gene activity in vivo.

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    Area of Science:

    • * Molecular Biology
    • * Genetics
    • * Cardiovascular Research

    Background:

    • * Transgenic mice are crucial for studying gene expression and function in vivo.
    • * Current methods allow cell-type-specific transgene expression.
    • * Many research models necessitate inducible or regulatable gene expression control.

    Purpose of the Study:

    • * To present the rationale for developing conditional transgenic systems.
    • * To review existing technologies for achieving regulated gene expression in vivo.
    • * To explore the potential of these systems in cardiovascular research.

    Main Methods:

    • * Review of existing literature on conditional transgenic technologies.
    • * Discussion of various systems enabling controlled transgene expression.
    • * Analysis of applications in studying gene regulation and function.

    Main Results:

    • * Conditional transgenics offer advanced control over transgene expression.
    • * Various systems exist to achieve highly regulated gene expression in vivo.
    • * These methods provide new avenues for investigating gene function.

    Conclusions:

    • * Conditional transgene expression is a powerful tool for biological research.
    • * These advanced transgenic models can significantly improve understanding of cardiovascular physiology and pathology.
    • * The development of regulated gene expression systems opens new frontiers in experimental biology.