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Duplicating autoimmune bullous diseases by passively transferring autoantibodies into animals

Mei Chen1, David T Woodley

  • 1USC Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

The Journal of Investigative Dermatology
|January 15, 2011
PubMed
Abstract

No abstract available in PubMed .

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
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Commonly used fusion techniques — electroporation, polyethylene glycol...