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Clustogenesis level in children with gastroduodenal diseases
F T Chshieva1, L V Chopikashvili, S K Djagaeva
1K L Khetagurov North Ossetian State University, Vladikavkaz, Russia. etoxlab@mail.ru
Bulletin of Experimental Biology and Medicine
|January 15, 2011
Summary
Children with Helicobacter pylori infections show increased chromosome damage. A supplement, vetoron, helped reduce this damage after treatment, suggesting a protective effect against clastogenesis.
Area of Science:
- Medical Science
- Genetics
- Microbiology
Background:
- Helicobacter pylori infection is linked to gastroduodenal diseases in children.
- Chromosome aberrations in lymphocytes can indicate genotoxic stress.
Purpose of the Study:
- To investigate chromosome aberration levels in children with H. pylori-associated diseases.
- To evaluate the impact of eradication therapy and vetoron supplementation on clastogenesis.
Main Methods:
- Analysis of chromosome aberrations in peripheral blood lymphocytes cultured for 72 hours.
- Monitoring changes after H. pylori eradication therapy.
- Assessing the effect of adding vetoron to treatment protocols.
Main Results:
- A higher mean count of cells with chromosome aberrations was observed in affected children.
- Eradication therapy led to increased clastogenesis in most children.
- Vetoron addition to treatment decreased clastogenesis manifestations.
Conclusions:
- H. pylori-associated gastroduodenal diseases are associated with increased genotoxicity in children.
- Standard eradication therapy may exacerbate clastogenesis.
- Vetoron shows potential in mitigating treatment-induced clastogenic effects.
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