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Updated: Jun 5, 2026

A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
In vitro evaluation of ketoprofen controlled release from various formulations
Ana-Maria Oprea1, Raluca Petronela Dumitriu, Cătălina Cheaburu
1Physical Chemistry of Polymers Department, P. Poni Institute of Macromolecular Chemistry laşi.
Unlabelled:
The aim of this study is to investigate the potential utility of some hydrogels, based on chitosan, chitosan modified with phthalic anhydride and 75/25 poly(N-isopropyl acrylamide)/alginate, for preparing drug release systems containing ketoprofen, as model drug.
Material And Method:
The in vitro release profiles and swelling studies were done in ethanol medium, where the studied drug presents high solubility, at 25 degrees C (room temperature). The ketoprofen release was observed by monitoring the absorbance at max = 254 nm as a function of time.
Results:
The experimental results indicated that the smallest amount of drug was released from chitosan matrices, appreciatively 31%.
Conclusions:
The composition of hydrogels had an important effect on ketoprofen release.
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