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Leukocyte migration inhibitory factor in HSV infections
Investigative Ophthalmology & Visual Science
|September 1, 1978
Summary
Individuals with recurrent herpes simplex virus (HSV) infections show an impaired cell-mediated immune (CMI) response between outbreaks. This suggests a weakened leukocyte migration inhibition factor (LMIF) production during the quiescent stage of HSV disease.
Area of Science:
- Immunology
- Virology
Background:
- Recurrent herpes simplex virus (HSV) infections are common and impact quality of life.
- The cell-mediated immune (CMI) response plays a crucial role in controlling viral infections.
Purpose of the Study:
- To investigate the CMI response in patients with recurrent HSV infections during their quiescent stage.
- To assess the production of leukocyte migration inhibition factor (LMIF) in these patients.
Main Methods:
- Assessed CMI response using a direct assay of LMIF.
- Calculated the migration index (MI) by comparing leukocyte migration with and without HSV antigens.
- Compared MI values between HSV patients and healthy control subjects.
Main Results:
- Healthy controls exhibited a positive CMI response (MI < 0.8) in 16.8% of cases.
- All tested patients with recurrent HSV infections had an MI > 0.8, indicating impaired LMIF production.
- The difference in MI between patients and controls was statistically significant (p < 0.001) and age-independent.
Conclusions:
- Individuals with recurrent HSV infections have an impaired CMI response between attacks.
- This impairment in LMIF production may be linked to the disease stage in recurrent HSV infections.