Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Retroviruses

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...

Viruses with RNA Genomes

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...

Influenza

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...

Introduction to Virus

Introduction to Virus

Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...

Coronavirus

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Exploring the role of sialidases in Galectin-1-associated resistance to cancer therapies.

Biochimica et biophysica acta. General subjects·2026

Same author

Glycan-Binding Proteins in Immunity.

Annual review of immunology·2026

Same author

TRPV4 channels mediate exacerbated response to mechanical cues in spontaneously hypertensive rats.

Journal of hypertension·2025

Same author

Platelet Releasate Reprograms Synovial Macrophages In Vitro: A New Approach in the Treatment of Hemophilic Synovitis.

International journal of molecular sciences·2025

Same author

Yellow fever virus infection triggers proinflammatory and prothrombotic responses in endothelial cells through NF-κB and MAPK signaling pathways.

Thrombosis research·2025

Same author

Yellow Fever Virus Induces Golgi Stress and CREB3L1 Nuclear Translocation in Human A549 Cells.

Journal of medical virology·2025

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Published on: March 2, 2016

Junín virus. A XXI century update.

Ricardo M Gómez¹, Carolina Jaquenod de Giusti, Maria M Sanchez Vallduvi

¹Biotechnology and Molecular Biology Institute, CONICET-UNLP, calle 49 y 115, 1900 La Plata, Argentina. rmg@biol.unlp.edu.ar

Microbes and Infection

|January 18, 2011

Summary

Junín virus causes Argentine hemorrhagic fever, a serious illness with bleeding and neurological issues. This review covers the virus, disease history, and how it causes illness.

More Related Videos

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Published on: December 29, 2015

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Published on: August 1, 2013

Related Experiment Videos

Last Updated: Jun 5, 2026

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Published on: March 2, 2016

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Published on: December 29, 2015

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Published on: August 1, 2013

Area of Science:

Virology
Infectious Diseases
Public Health

Background:

Junín virus (JUNV) is a member of the Arenaviridae family.
JUNV is the causative agent of Argentine hemorrhagic fever (AHF).
AHF presents with significant hematological and neurological manifestations.

Purpose of the Study:

To provide a historical perspective on Argentine hemorrhagic fever.
To consolidate current knowledge regarding Junín virus.
To update information on the JUNV virion structure and pathogenesis.

Main Methods:

Literature review of historical and current research on Junín virus and AHF.
Synthesis of data on viral characteristics.
Analysis of proposed pathogenic mechanisms.

Main Results:

Established the etiological link between Junín virus and Argentine hemorrhagic fever.
Detailed the clinical presentation of AHF, including hematological and neurological symptoms.
Summarized current understanding of the Junín virus virion and its replication cycle.

Conclusions:

Junín virus remains a significant public health concern in endemic regions.
Further research into pathogenic mechanisms may reveal therapeutic targets.
Comprehensive understanding of the virus is crucial for disease management and prevention.