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Related Concept Videos

Flail Chest-II01:26

Flail Chest-II

Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
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History:
Pulmonary Function Tests01:25

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Oxygen Delivering System III: Tracheostomy and T-piece01:23

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Related Experiment Video

Updated: Jun 5, 2026

A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation
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Vertical expandable prosthetic titanium rib device insertion: does it improve pulmonary function?

Samir K Gadepalli1, Ronald B Hirschl, Wan C Tsai

  • 1C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI 48105, USA. samirg@med.umich.edu

Journal of Pediatric Surgery
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Vertical Expandable Prosthetic Titanium Rib (VEPTR) surgery showed mild improvement in scoliosis angles but did not significantly enhance lung function or volume in pediatric patients. Patient functional status remained largely unchanged post-procedure.

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Area of Science:

  • Pediatric Orthopedics
  • Thoracic Surgery
  • Pulmonology

Background:

  • Thoracic insufficiency syndrome (TIS) necessitates interventions to improve thoracic volume and lung function.
  • Vertical Expandable Prosthetic Titanium Rib (VEPTR) is a surgical device designed to address TIS by expanding the thoracic cage.
  • Assessing the efficacy of VEPTR in pediatric patients is crucial for optimizing treatment strategies.

Purpose of the Study:

  • To evaluate the impact of VEPTR implantation on thoracic volume and pulmonary function in patients with TIS.
  • To assess the functional status and quality of life of children undergoing VEPTR procedures.
  • To determine the effectiveness of VEPTR in controlling scoliosis progression in this patient population.

Main Methods:

  • A retrospective review of 26 patients who underwent 29 VEPTR insertions and 57 expansions between 2006 and 2010.
  • Data collected included demographic information, complications, scoliosis angles (Cobb measurement), pulmonary function tests (PFTs), and lung volumes via CT scans.
  • Quality of life was assessed using the modified Scoliosis Research Society (SRS) questionnaire, with analyses stratified by age, disease type, and sex.

Main Results:

  • Patients underwent an average of 3.03 surgeries, with infection being the most common complication (12 cases).
  • Postoperative PFTs and lung volumes showed no significant improvement compared to preoperative values.
  • A 29% improvement in major scoliosis curves was observed postoperatively, though curves slightly increased at final follow-up (3%). SRS scores remained unchanged.

Conclusions:

  • VEPTR implantation resulted in mild improvement in scoliosis angles but did not significantly enhance pulmonary function or lung volumes.
  • Patient-reported functional status, as measured by SRS scores, showed no significant change after VEPTR placement.
  • The study suggests that while VEPTR may offer some benefit for scoliosis, its impact on lung function and overall quality of life in TIS patients is limited.