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Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
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Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

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Meiosis vs. Mitosis02:57

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Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
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Do patients with Down syndrome develop appendicitis?

M Elizabeth N Lewis1, Michael W L Gauderer, Dawn W Blackhurst

  • 1Division of Pediatric Surgery, Department of Pediatrics, Children's Hospital, Greenville Hospital System University Medical Center, Greenville, South Carolina 29605-4253, USA.

Journal of Pediatric Surgery
|January 18, 2011
PubMed
Summary
This summary is machine-generated.

The incidence of acute appendicitis (AA) is significantly lower in individuals with Down syndrome (DS) compared to the general population. This finding is crucial for diagnosing abdominal conditions in patients with DS.

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Area of Science:

  • Medical research
  • Clinical epidemiology
  • Down syndrome studies

Background:

  • Acute appendicitis (AA) is common in the general population.
  • Clinical observations suggest AA is less frequent in individuals with Down syndrome (DS).

Purpose of the Study:

  • To investigate if the incidence of AA is significantly reduced in patients with DS.
  • To compare AA incidence between DS patients and the general population.

Main Methods:

  • A 13-year cross-sectional study using state hospital discharge data.
  • Estimation of annual AA incidence in pediatric and adult populations with and without DS.
  • Comparison of incidence rates using 95% confidence intervals.

Main Results:

  • Pediatric AA incidence: 2.5 per 1000 in DS vs. 8.9 per 1000 in the general population.
  • Adult AA incidence: 2.7 per 1000 in DS vs. 5.7 per 1000 in the general population.

Conclusions:

  • AA incidence is markedly lower in individuals with DS.
  • This reduced incidence is important for evaluating acute abdominal conditions in the DS population.
  • The biological reasons for this difference require further investigation.