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Updated: Jun 5, 2026

A Swine Model of Neonatal Asphyxia
10:36

A Swine Model of Neonatal Asphyxia

Published on: October 11, 2011

Shock: a common consequence of neonatal asphyxia.

Tina A Leone1, Neil N Finer

  • 1Department of Pediatrics, University of California, San Diego, CA 92103, USA. tleone@ucsd.edu

The Journal of Pediatrics
|January 18, 2011
PubMed
Summary

Neonatal asphyxia causes organ damage and circulatory issues. While hypothermia therapy aids recovery without harming cardiovascular stability, treatments targeting the cardiovascular system show only short-term benefits for blood flow.

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Last Updated: Jun 5, 2026

A Swine Model of Neonatal Asphyxia
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The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation
09:03

The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation

Published on: August 15, 2018

Area of Science:

  • Neonatology
  • Cardiovascular Physiology
  • Perinatal Medicine

Background:

  • Neonatal asphyxia leads to multi-organ hypoxia-ischemia and dysfunction.
  • The cardiovascular system is commonly impacted, presenting as shock and complicating circulatory transition.
  • Effective management strategies for cardiovascular compromise are crucial.

Purpose of the Study:

  • To evaluate the impact of hypothermia therapy on cardiovascular stability in neonatal asphyxia.
  • To assess the efficacy of cardiovascular-directed therapies in improving outcomes.
  • To determine if short-term improvements in systemic blood flow translate to long-term benefits.

Main Methods:

  • Review of existing literature on neonatal asphyxia and cardiovascular complications.
  • Analysis of studies investigating hypothermia therapy's effects.
  • Examination of trials employing cardiovascular support strategies.

Main Results:

  • Hypothermia therapy improves outcomes in neonatal asphyxia without compromising cardiovascular stability.
  • Cardiovascular-directed therapies can enhance short-term systemic blood flow measures.
  • No current cardiovascular therapies have demonstrated improvement in long-term outcomes.

Conclusions:

  • Hypothermia is a safe and effective intervention for neonatal asphyxia regarding cardiovascular function.
  • While short-term hemodynamic improvements are achievable, long-term benefits of cardiovascular-specific treatments remain unproven.
  • Further research is needed to identify interventions that improve long-term outcomes for neonates with asphyxia-related cardiovascular dysfunction.