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Published on: January 18, 2019
Signal transduction through G proteins in the cardiac myocyte
1Department of Medicine, Brigham UK; Women's Hospital and Harvard Medical School, Boston, MA 02115 USA.
Abstract:
The membrane of the cardiocyte contains a large variety of molecules whose function is to transmit signals from outside the cell to inside. The signals are initiated by receptors for a variety of agonists and propagated by a family of heterotrimeric G proteins to ion channels and intracellular enzymes. The large complement of receptors, G proteins, and effectors found in the cardiocyte raises fundamental questions about the mechanisms that assure the precision and timing of the heart cell's response to external stimuli.
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