Related Experiment Video

Updated: Jun 5, 2026

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage
07:57

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage

Published on: April 23, 2017

Comparison of ionic and low-osmolar contrast media during cardiac catheterization

C J Davidson1, T M Bashore

  • 1Duke University Medical Center, Department of Medicine, Division of Cardiology, Durham, NC 27710, USA.

Trends in Cardiovascular Medicine
|January 18, 2011
PubMed

Insights

Nonionic contrast agents reduce cardiovascular complications during cardiac catheterization compared to ionic contrast. However, their higher cost and similar nephrotoxicity and thrombotic event rates require careful consideration.

Area of Science:

  • Cardiology
  • Radiology
  • Nephrology

Background:

  • Ionic contrast agents are commonly used in cardiac catheterization.
  • Cardiovascular complications and nephrotoxicity are potential risks associated with contrast agents.

Purpose of the Study:

  • To compare the safety and efficacy of nonionic versus ionic contrast agents in cardiac catheterization.
  • To evaluate cardiovascular complications, hemodynamic effects, electrophysiologic effects, nephrotoxicity, and thrombotic events.

Main Methods:

  • Review of existing clinical data comparing ionic and nonionic contrast agents.
  • Analysis of outcomes including major and minor cardiovascular complications, hemodynamic and electrophysiologic changes, renal function, and thrombotic events.

Main Results:

  • Nonionic contrast agents significantly decrease major and minor cardiovascular complications compared to ionic agents.
  • Hemodynamic and electrophysiologic effects are less pronounced with nonionic agents, particularly in patients with severe coronary artery disease or left ventricular dysfunction.
  • Nephrotoxicity and thrombotic event rates appear similar between ionic and nonionic agents, though some benefit for renal dysfunction may exist with nonionic agents.

Conclusions:

  • Nonionic contrast agents offer reduced cardiovascular risk during cardiac catheterization.
  • The higher cost of nonionic agents must be balanced against their benefits.
  • Further research is needed to clarify nephrotoxic differences and outcomes in specific patient populations like those undergoing percutaneous transluminal coronary angioplasty.

More Related Videos

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise07:09

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise

Published on: February 20, 2017

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Related Concept Videos

Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
Cardiac Catheterization IV: Nursing Management01:26

Cardiac Catheterization IV: Nursing Management

Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and the...