Related Experiment Video

Updated: Jun 5, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

Apolipoprotein E gene polymorphism in men with coronary atherosclerosis in Siberia

E V Shakhtshneider1, Yu I Ragino, A M Chernjavski

  • 1Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. 2117409@mail.ru

Bulletin of Experimental Biology and Medicine
|January 18, 2011
PubMed

Insights

Genetic variations in the APOE gene are linked to coronary atherosclerosis risk factors in West Siberian men. Specific APOE genotypes correlate with cholesterol levels, impacting cardiovascular health.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Coronary atherosclerosis is a leading cause of mortality.
  • The apolipoprotein E (APOE) gene plays a role in lipid metabolism.
  • Understanding APOE gene polymorphism may offer insights into atherosclerosis risk.

Purpose of the Study:

  • To investigate the association between APOE gene coding fragment polymorphism and lipid risk factors for coronary atherosclerosis in West Siberian men.
  • To compare lipid profiles in relation to APOE genotypes between patients with coronary atherosclerosis and a reference group.

Main Methods:

  • Genotyping of the APOE gene coding fragment.
  • Analysis of lipid profiles, including total cholesterol and LDL cholesterol.
  • Statistical analysis to determine associations between genotypes and risk factors.

Main Results:

  • Statistically significant associations were found between APOE genotypes and key lipid risk factors for coronary atherosclerosis in West Siberian men.
  • Elevated total cholesterol levels were observed in Novosibirsk men carrying the APOE ε4 allele.

Conclusions:

  • APOE gene polymorphism is associated with lipid risk factors for coronary atherosclerosis in the West Siberian male population.
  • The presence of the ε4 allele in APOE genotypes may be linked to higher cholesterol levels, suggesting a potential role in atherosclerosis development.

More Related Videos

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes08:35

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

Published on: July 17, 2021

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters01:16

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...