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Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
New phenolic compounds from Meehania urticifolia
Toshihiro Murata1, Toshio Miyase, Fumihiko Yoshizaki
1Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai 981-8558, Japan. murata-t@tohoku-pharm.ac.jp
Journal of Natural Medicines
|January 18, 2011
Summary
Researchers identified novel compounds, including rashomoside A and B, from Meehania urticifolia. Spectroscopic analysis confirmed the structures of these new natural products and others isolated from the plant.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Pharmacognosy
Background:
- Meehania urticifolia is a plant species with potential medicinal properties.
- The chemical constituents of Meehania urticifolia have not been extensively studied.
Purpose of the Study:
- To isolate and characterize new chemical compounds from Meehania urticifolia.
- To elucidate the structures of these novel compounds using spectroscopic methods.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation employing Nuclear Magnetic Resonance (NMR) spectroscopy and Mass Spectrometry (MS).
Main Results:
- Three new compounds were identified: rashomoside A (a phenylethanoid glycoside), rashomoside B (a phenolic glucoside), and a shikimic acid derivative.
- Twelve known flavones, three known phenylethanoid glycosides, and thirteen other known compounds were also isolated.
- The structures of all isolated compounds were determined through comprehensive spectroscopic analysis.
Conclusions:
- The phytochemical investigation of Meehania urticifolia led to the discovery of novel natural products.
- This study expands the knowledge of the chemical diversity within the Meehania genus.

