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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Related Experiment Video

Updated: Jun 5, 2026

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples
08:58

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples

Published on: April 12, 2015

Stem cells in clinical practice: applications and warnings.

Daniele Lodi1, Tommaso Iannitti, Beniamino Palmieri

  • 1Department of Nephrology, Dialysis and Transplantation, University of Modena and Reggio Emilia Medical School, Modena, Italy.

Journal of Experimental & Clinical Cancer Research : CR
|January 19, 2011
PubMed
Summary

This review examines human stem cell applications for treating degenerative diseases, focusing on therapeutic benefits, risks, and ethical considerations in clinical trials.

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Area of Science:

  • Regenerative Medicine
  • Cell Biology
  • Biotechnology

Background:

  • Stem cells offer insights into cellular differentiation and tissue repair.
  • They hold significant potential for treating degenerative diseases.
  • Understanding stem cell subtypes is crucial for medical applications.

Purpose of the Study:

  • To review clinical and experimental applications of human stem cells.
  • To provide a clear overview of available stem cell subtypes.
  • To analyze therapeutic benefits, side effects, and ethical issues of stem cell therapy.

Main Methods:

  • Searched PubMed/Medline for clinical trials using "stem cells" and related keywords.
  • Included relevant clinical trials focusing on transplantation, pathology, guidelines, properties, and risks.
  • Categorized results based on stem cell application in various pathological conditions.

Main Results:

  • Clinical trials were reviewed and categorized by application.
  • Analysis considered stem cell properties, risks, and therapeutic outcomes.
  • Ethical considerations associated with stem cell therapy were addressed.

Conclusions:

  • Human stem cells are promising for treating degenerative diseases.
  • Rational use requires understanding subtypes, benefits, and risks.
  • Further research and ethical guidelines are essential for clinical translation.