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Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
Published on: May 30, 2016
Skin tissue engineering--in vivo and in vitro applications
Florian Groeber1, Monika Holeiter, Martina Hampel
1Department of Cell and Tissue Engineering, Fraunhofer-Institute for Interfacial Engineering and Biotechnology (IGB), Nobelstrasse 12, Stuttgart, Germany. katja.schenke-layland@igb.fraunhofer.de
Advanced Drug Delivery Reviews
|January 19, 2011
Summary
Tissue-engineered skin substitutes show promise for skin grafts and in vitro models. Novel disease-in-a-dish models advance research in disease and drug discovery.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Tissue Engineering
Background:
- Significant advancements in developing in vitro-engineered skin substitutes have been achieved.
- These engineered tissues serve dual purposes: as grafts for skin replacement and as human-based in vitro skin models.
Purpose of the Study:
- To review progress in in vivo and in vitro applications of tissue-engineered skin.
- To highlight novel approaches in creating complex disease-in-a-dish models.
Main Methods:
- Literature review of in vivo and in vitro tissue-engineered skin applications.
- Analysis of emerging strategies for complex disease modeling.
Main Results:
- Engineered skin substitutes have progressed significantly for therapeutic and research applications.
- Novel disease-in-a-dish models are being developed for various research needs.
Conclusions:
- Tissue-engineered skin offers viable solutions for skin regeneration and advanced in vitro modeling.
- The development of sophisticated disease models is crucial for understanding disease mechanisms and accelerating drug development.
