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Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
Published on: September 27, 2019
Preparation and characterization of a three-dimensional printed scaffold based on a functionalized polyester for bone
Hajar Seyednejad1, Debby Gawlitta, Wouter J A Dhert
1Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands.
Acta Biomaterialia
|January 19, 2011
Summary
New hydroxyl functionalized polymer scaffolds show promise for bone tissue engineering. These poly(hydroxymethylglycolide-co-ε-caprolactone) scaffolds support cell growth and osteogenic differentiation, offering a potential solution for bone regeneration needs.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Polymer Chemistry
Background:
- There is a significant demand for advanced scaffolds in bone tissue engineering.
- Poly(hydroxymethylglycolide-co-ε-caprolactone) (pHMGCL) has emerged as a promising material for bone regeneration.
- Existing scaffolds often lack the optimal properties for effective bone defect repair.
Purpose of the Study:
- To evaluate the suitability of porous pHMGCL scaffolds for bone tissue engineering applications.
- To compare the performance of pHMGCL scaffolds with poly(ε-caprolactone) (PCL) scaffolds.
- To assess cell interaction, viability, and differentiation on pHMGCL scaffolds.
Main Methods:
- Fabrication of porous scaffolds using a three-dimensional plotting technique.
- Characterization of thermal and mechanical properties of pHMGCL and PCL scaffolds.
- Seeding of human mesenchymal stem cells onto scaffolds to assess attachment, viability, and osteogenic differentiation.
Main Results:
- pHMGCL and PCL scaffolds exhibited high porosity and interconnected pore structures.
- Human mesenchymal stem cells readily infiltrated pHMGCL scaffolds within 7 days.
- Cells on pHMGCL scaffolds demonstrated enhanced metabolic activity and supported osteogenic differentiation compared to PCL scaffolds.
Conclusions:
- pHMGCL-based porous scaffolds are suitable for bone tissue engineering.
- These scaffolds provide a favorable microenvironment for human mesenchymal stem cell proliferation and osteogenic differentiation.
- pHMGCL scaffolds represent a promising template for future bone regeneration strategies.
