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Are polycomb group bodies gene silencing factories?
Jacob W Hodgson1, Hugh W Brock
1Department of Zoology, University of British Columbia, Vancouver BC, Canada.
Abstract:
Polycomb group (PcG) proteins mediate long-range associations between Hox genes, which correlate with gene repression in vivo. Bantignies et al. (2011) identify a physiological role for the nuclear localization of Hox genes in PcG-mediated gene silencing, strengthening the evidence that nuclear positioning regulates gene expression.
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