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Related Experiment Video

Updated: Jun 5, 2026

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

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The Solid State X-ray Image Intensifier (SSXII) in Single Photon Counting (SPC) mode.

Andrew Kuhls-Gilcrist¹, Amit Jain, Daniel R Bednarek

¹University at Buffalo (State University of New York), Toshiba Stroke Research Center, 3435 Main St., Buffalo, NY USA 14214.

Proceedings of Spie--The International Society for Optical Engineering

|January 19, 2011

Summary

The new Solid State X-Ray Image Intensifier (SSXII) offers improved resolution in single photon counting (SPC) mode compared to traditional energy integrating (EI) mode. This advancement benefits applications requiring high spatial resolution, like mammography.

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Area of Science:

Medical Imaging
X-ray Detector Technology

Background:

Traditional X-ray imaging often uses energy integrating (EI) mode, which can be limited in resolution.
Developing advanced detectors is crucial for improving diagnostic accuracy in medical imaging.

Purpose of the Study:

To evaluate the performance of a new Solid State X-Ray Image Intensifier (SSXII) in both single photon counting (SPC) and energy integrating (EI) modes.
To compare the spatial resolution capabilities of the SSXII in its two operating modes.

Main Methods:

The SSXII, utilizing an electron-multiplying CCD (EMCCD), was tested in both SPC and EI modes.
Presampled Modulation Transfer Function (MTF) was measured using the angulated-slit method at various spatial frequencies.
A thresholding technique was employed to process SPC mode data.

Main Results:

The SSXII in SPC mode demonstrated significantly higher MTF values across all tested spatial frequencies compared to EI mode.
For instance, at 2.5 cycles/mm, SPC MTF was 0.67 versus 0.20 for EI.
A trade-off between resolution and count efficiency was observed in SPC mode, influenced by threshold levels.

Conclusions:

The SSXII operating in SPC mode offers substantial resolution improvements over traditional EI mode.
This enhanced resolution is particularly beneficial for medical applications with stringent spatial resolution demands, such as mammography.