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Updated: Jun 5, 2026
Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments
Published on: May 31, 2017
[Effect of decoction method on pharmacokinetics of puerarin in dogs]
1Heilongjiang University of Chinese Medicine, Harbin 150076, China. kurb@sohu.com
Objective:
To investigate the effect of decoction method on pharmacokinetics of Puerarin by determining Puerarin concentration of serum after administration of Gegenqinlian in single (D) and mixed decoction (H) to dogs.
Methods:
HPLC method was established to determine serum concentration of Puerarin and pharmacokinetic parameters were calculated.
Results:
The parameters in dogs after administration of H and D were as follows: C(max) was (5.164 +/- 0.637) and (5.383 +/- 0.818) microg/mL, t(max) was (1.10 +/- 0.374) and (1.25 +/- 0.274) h, AUC(0-t) was (25.76 +/- 5.48) and (27.97 +/- 7.16) microg/(h x mL), respectively.
Conclusion:
Decoction method has significant effect on pharmacokinetic parameters of puerarin in dogs.