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Selectivity control in alkylidene carbene-mediated C-H insertion and allene formation

Jun-Cheng Zheng1, Sang Young Yun, Chunrui Sun

  • 1Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, USA.

The Journal of Organic Chemistry
|January 20, 2011
PubMed
Summary

Electronic effects dominate regioselectivity in alkylidene carbene C-H insertion reactions, surpassing steric influences. This understanding enables precise control over carbene insertion into various C-H bonds.

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