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Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation

F C Church1, M R Hoffman

  • 1Departments of Pthology and Medicine and the Center for Thrombosis and Hemostasis, School of Medicine, University of North Carolina, Chapel Hill, USA.

Trends in Cardiovascular Medicine
|January 20, 2011
PubMed
Summary

Heparin cofactor II specifically inhibits thrombin, a key proteinase in blood coagulation and wound healing. Both molecules interact with glycosaminoglycans and influence inflammatory processes.

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