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Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
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Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

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Related Experiment Video

Updated: Jun 5, 2026

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

Lymph node stromal cells strongly influence immune response suppression.

Manuela Buettner1, Reinhard Pabst, Ulrike Bode

  • 1Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.

European Journal of Immunology
|January 20, 2011
PubMed
Summary
This summary is machine-generated.

Peripheral lymph node stromal cells promote oral tolerance by inducing B cell accumulation and antibody production, influencing immune responses to gut pathogens.

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Last Updated: Jun 5, 2026

Isolation of Murine Lymph Node Stromal Cells
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09:10

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Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow
11:30

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow

Published on: January 7, 2015

Area of Science:

  • Immunology
  • Gastroenterology

Background:

  • The gut is a primary site for encountering pathogens, necessitating immune responses or tolerance.
  • Mesenteric lymph nodes (mLNs) are crucial for oral tolerance induction.
  • Lymph node (LN) stromal cells shape T-cell function and IgA responses.

Purpose of the Study:

  • To investigate the role of LN stromal cells in oral tolerance induction.
  • To compare the effects of mLN and peripheral LN (pLN) stromal cells on immune responses.

Main Methods:

  • Transplantation of mLNs or pLNs into mice (mLNtx or pLNtx).
  • Oral tolerance induction using ovalbumin.
  • Assessment of delayed-type hypersensitivity (DTH) response.
  • Analysis of IL-10 expression, regulatory T cells (Tregs), B cells, and immunoglobulin production.

Main Results:

  • pLNtx mice showed reduced DTH responses compared to mLNtx mice.
  • pLNtx exhibited decreased IL-10, fewer Tregs, and more B cells.
  • Increased B cells in pLNtx led to specific immunoglobulin production.
  • Transferred IgG(+) cells from tolerized pLNs significantly reduced DTH response.

Conclusions:

  • LN stromal cells significantly impact the immune microenvironment.
  • pLN stromal cells induce a tolerogenic phenotype characterized by B cell accumulation and antibody production.
  • Stromal cell-driven B cell responses are key in oral tolerance.