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Trifunctionalization of the purine scaffold using Mg and Zn organometallic intermediates
Silvia Zimdars1, Xavier Mollat du Jourdin, François Crestey
1Department Chemie & Biochemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 München, Germany.
Abstract:
Starting from an appropriate 6-chloro-2-TMS-purine derivative, a regioselective functionalization of the purine scaffold was achieved successively at positions 8, 6, and 2 via zinc and magnesium intermediates which were generated either by a direct zincation with TMPZnCl·LiCl or by an I/Mg exchange with iPrMgCl.
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