Mean platelet volume: a link between thrombosis and inflammation?
Armen Yuri Gasparyan1, Lilit Ayvazyan, Dimitri P Mikhailidis
1Clinical Research Unit, Russell’s Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, West Midlands, UK. a.gasparyan@gmail.com
Current Pharmaceutical Design
|January 21, 2011
Summary
Mean platelet volume (MPV) is a marker linked to thrombosis and inflammation. Higher MPV indicates increased thrombosis risk, while high-grade inflammation can lower MPV.
Area of Science:
- Hematology
- Clinical Pathology
- Cardiovascular Medicine
Background:
- Platelet activation plays a key role in thrombosis and inflammation.
- Mean platelet volume (MPV) is a platelet marker investigated for its association with these conditions.
- MPV is influenced by various factors, including cardiovascular risks and inflammatory states.
Purpose of the Study:
- To review MPV as a prognostic and therapeutic marker.
- To examine factors influencing MPV measurements.
- To explore the relationship between MPV and thrombotic and inflammatory conditions.
Main Methods:
- Literature review of studies investigating MPV.
- Analysis of evidence from prospective studies and meta-analyses.
- Consideration of confounding factors such as cardiovascular risk factors and inflammation.
Main Results:
- Elevated MPV correlates with an increased risk of thrombosis.
- High MPV is associated with cardiovascular and cerebrovascular disorders and low-grade inflammation.
- High-grade inflammatory diseases show low MPV, which normalizes with anti-inflammatory therapy.
Conclusions:
- MPV serves as a potential prognostic and therapeutic marker in thrombotic and inflammatory diseases.
- Cardiovascular risk factors and inflammation significantly influence MPV levels.
- Further prospective studies are needed to confirm the impact of lifestyle and medical therapies on MPV and thrombotic outcomes.
More Related Videos
Related Concept Videos
01:38Inflammation
Overview
01:22Formation of the Platelet Plug
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
01:18Structure and Function of Platelets
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
01:30Venous Thrombosis I: Introduction
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
01:25Acute Inflammation III: Local and Systemic Effects
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...