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Updated: Sep 3, 2026

Analysis of Epididymal Protein Synthesis and Secretion
Published on: August 25, 2018
Histology of the epididymis in men with obstructive infertility
M Rajalakshmi1, B V Kumar, P R Ramakrishnan
1Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi.
Abstract:
The histology of different regions of human epididymis in men undergoing vasoepididymostomy to correct epididymal obstruction was studied. The data indicate major degenerative changes in intertubular connective tissue and in the epididymal epithelium. These include increase in connective tissue thickness and its infiltration by leucocytes in some cases, decrease in tubular diameter, degeneration and/or vacuolation of cytoplasm of nonciliated cells of efferent duct and principal cells of epididymis and presence of multinucleate giant cells in the epididymal lumen. These histological abnormalities are discussed in relation to the role such epididymis can play in sperm maturation following vasoepididymostomy.
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