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The clinical importance in differentiating portal from mesenteric venous thrombosis

S Acosta1, A Alhadad, H Verbaan

  • 1Vascular Centre, Malmö University Hospital, Malmö, Sweden. Stefan.acosta@telia.com

International Angiology : a Journal of the International Union of Angiology
|January 21, 2011
PubMed
Abstract

Insights

Mesenteric vein thrombosis (MVT) significantly increases the risk of intestinal infarction and venous thromboembolism. Portal vein thrombosis (PVT) without MVT extension is linked to liver disease, not infarction.

Area of Science:

  • Vascular Medicine
  • Gastroenterology
  • Thrombosis Research

Background:

  • Portomesenteric venous thrombosis (PMVT) is a complex condition with varying clinical implications.
  • Understanding the distinct risks associated with mesenteric vein thrombosis (MVT) versus portal vein thrombosis (PVT) is crucial for patient management.

Purpose of the Study:

  • To investigate the relationship between the extent of portomesenteric venous thrombosis and the risk of intestinal infarction.
  • To determine the association of PMVT with concomitant venous thromboembolism and underlying diseases.

Main Methods:

  • A retrospective analysis of clinical cases of MVT and PVT (2000-2006) was conducted.
  • An autopsy cohort of 24,000 cases (1970-1982) was reviewed to identify PMVT prevalence and outcomes.

Main Results:

  • MVT cases showed a higher incidence of thrombophilic disorders and intestinal infarction compared to PVT.
  • Autopsy findings revealed that 29 out of 31 MVT cases had intestinal infarction, while none of the PVT cases without MVT extension did.
  • Portomesenteric venous thrombosis with intestinal infarction was strongly associated with concomitant venous thromboembolism (OR 6.1).

Conclusions:

  • Mesenteric vein thrombosis (MVT) is a significant risk factor for intestinal infarction and venous thromboembolism.
  • Portal vein thrombosis (PVT) without extension to the superior mesenteric vein is primarily associated with underlying liver disease.

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