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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Thyroid disorders and hypercoagulability.
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. cihangirerem@hotmail.com
Seminars in Thrombosis and Hemostasis
|January 21, 2011
Summary
Thyroid dysfunction can alter blood clotting and fibrinolysis, impacting hemostasis. Further research is needed to fully understand these coagulation abnormalities in thyroid disease patients.
Area of Science:
- Endocrinology
- Hematology
Background:
- Thyroid diseases are associated with various hemostasis abnormalities.
- These range from subclinical findings to significant bleeding or clotting disorders.
Purpose of the Study:
- To review the relationship between thyroid dysfunction and the coagulation/fibrinolytic system.
- To synthesize current literature on hemostatic changes in thyroid disease.
Main Methods:
- Literature review of recent studies.
- Analysis of the direct effects of thyroid hormones on hemostatic parameters.
- Consideration of thyroid autoimmunity's role.
Main Results:
- Hyperthyroidism typically presents with hypercoagulability and hypofibrinolysis.
- Hypothyroidism shows variable hemostatic profiles, including hypercoagulable or hypocoagulable states.
- Limited data exists for subclinical thyroid disease hemostasis.
Conclusions:
- Thyroid hormone levels directly influence coagulation and fibrinolysis.
- Thyroid autoimmunity can also affect secondary hemostasis.
- High-quality prospective studies are required to clarify coagulation abnormalities in thyroid disease.
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