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3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
Published on: December 9, 2014
Controversies in ocular toxoplasmosis
Denis Wakefield1, Emmett T Cunningham, Carlos Pavesio
1St Vincents Eye Clinic and School of Medical Sciences, University of New Sourth Wales, Sydney. Australia.
Ocular Immunology and Inflammation
|January 22, 2011
Summary
Ocular toxoplasmosis diagnosis shows expert consensus on clinical signs but less on triggers. Treatment varies widely, with few experts recommending recurrence prophylaxis.
Area of Science:
- Ophthalmology
- Immunology
- Infectious Diseases
Background:
- Toxoplasmosis is a leading cause of infectious uveitis.
- Ocular Immunology and Inflammation designated it the disease of the year in 2011.
- Expert consensus on ocular toxoplasmosis is crucial for patient care.
Purpose of the Study:
- To survey leading uveitis experts on key issues in ocular toxoplasmosis.
- To assess consensus on diagnosis, pathophysiology, and treatment.
- To identify areas of agreement and disagreement among specialists.
Main Methods:
- A survey was distributed to leading uveitis experts.
- Participants were asked about diagnosis, pathophysiology, and treatment.
- Responses were analyzed to identify areas of consensus and divergence.
Main Results:
- Strong consensus exists on clinical signs of typical and atypical toxoplasmic retinochoroiditis.
- Less consensus was found regarding diagnostic approaches, epidemiology, transmission, and triggers.
- A wide variety of drug regimens are used for both congenital and acquired toxoplasmosis.
- Recurrence prophylaxis is not regularly recommended by most experts.
Conclusions:
- While clinical signs are well-defined, diagnostic and etiological aspects of ocular toxoplasmosis require further clarification.
- Current treatment strategies for ocular toxoplasmosis are diverse.
- Prophylaxis against recurrence is underutilized by experts.
- Further research is needed to standardize diagnosis and treatment protocols.
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