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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

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Published on: July 17, 2012

New developments in fluorescence diagnostics.

Juraj Hegyi¹, Vladimir Hegyi, Thomas Ruzicka

¹Department of Dermatology, Ludwig-Maximilian University, Munich, Germany. juraj@dermatology.sk

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

|January 22, 2011

Summary

This summary is machine-generated.

Recent advances in skin imaging allow for non-invasive diagnosis of skin conditions. This review covers 100 years of fluorescence imaging, highlighting its role in modern dermatology and autofluorescence detection.

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Area of Science:

Dermatology
Medical Imaging
Biophotonics

Background:

Significant advancements in direct skin visualization have occurred in the past decade.
Non-invasive in vivo analysis of skin diseases is now possible with specialized skin imaging devices.
These devices offer superior detail of skin structure and properties compared to visual examination.

Purpose of the Study:

To review the historical development of fluorescence imaging over the last century.
To discuss the application of fluorescence diagnostics (FD) in contemporary dermatology.
To address the detection of autofluorescence in skin.

Main Methods:

Historical review of fluorescence imaging techniques.
Analysis of clinical observations and advanced spectral imaging.
Examination of the role of fluorescence diagnostics in dermatological practice.

Main Results:

Fluorescence imaging has evolved from basic clinical observation to sophisticated spectral analysis.
Specialized devices enable detailed, non-invasive in vivo skin examination.
Fluorescence diagnostics (FD) plays a crucial role in modern dermatological disease detection.

Conclusions:

Fluorescence imaging represents a century of progress in understanding skin structure and disease.
Non-invasive diagnostic tools, particularly those utilizing fluorescence, are transforming dermatology.
Autofluorescence detection is an important aspect of these advanced imaging modalities.