Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hypersensitivity Reactions: Immune-Complex Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

Endocarditis IV: Nursing Management

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...

Drug Toxicity: Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...

Intrauterine Drug Delivery Systems

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Assisted reproductive technology for patients with medical comorbidities.

Current opinion in obstetrics & gynecology·2026

Same author

3D Modeling of a Myometrially Embedded Intrauterine Device.

Journal of minimally invasive gynecology·2026

Same author

Updates and innovations in reproductive medicine.

Current opinion in obstetrics & gynecology·2025

Same author

Radiofrequency Ablation for the Treatment of Uterine Fibroids: A Systematic Review and Meta-Analysis by the AAGL Practice Committee.

Journal of minimally invasive gynecology·2024

Same author

Obesity and reproduction.

Current opinion in obstetrics & gynecology·2022

Same author

Reoperation rates for recurrence of fibroids after abdominal myomectomy in women with large uterus.

PloS one·2021

Same journal

The Political Determinants of Obstetric Prescribing.

Obstetrics and gynecology·2026

Same journal

Glucagon-Like Peptide-1 Receptor Agonists and Risk of Adverse Maternal Pregnancy Outcomes: A Systematic Review and Meta-analysis.

Obstetrics and gynecology·2026

Same journal

Milestones in Motion: Vaginal Birth After Cesarean.

Obstetrics and gynecology·2026

Same journal

Ebola Virus in Pregnancy.

Obstetrics and gynecology·2026

Same journal

A Quality-Improvement Study Evaluating Three Postpartum Prophylactic Oxytocin Rates and Blood Loss After Vaginal Birth.

Obstetrics and gynecology·2026

Same journal

The Effects of Climate Change on Obstetric and Gynecologic Health.

Obstetrics and gynecology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Published on: November 13, 2019

Nickel hypersensitivity associated with an intratubal microinsert system.

Zain Al-Safi¹, Valerie I Shavell, Lon E Katz

¹From the Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan; and the Detroit Medical Center, Detroit, Michigan.

Obstetrics and Gynecology

|January 22, 2011

Summary

This summary is machine-generated.

Nickel hypersensitivity can occur with intratubal microinserts, even if previously unknown. Prompt diagnosis and hysteroscopic removal of these devices can resolve allergic reactions.

More Related Videos

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Rapid Formation and Testing of Self-expanding NiTi Frames with a Small Form Factor Suitable for Minimally Invasive Implants

Rapid Formation and Testing of Self-expanding NiTi Frames with a Small Form Factor Suitable for Minimally Invasive Implants

Published on: March 7, 2025

Related Experiment Videos

Last Updated: Jun 5, 2026

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Published on: November 13, 2019

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Rapid Formation and Testing of Self-expanding NiTi Frames with a Small Form Factor Suitable for Minimally Invasive Implants

Rapid Formation and Testing of Self-expanding NiTi Frames with a Small Form Factor Suitable for Minimally Invasive Implants

Published on: March 7, 2025

Area of Science:

Reproductive Medicine
Allergy and Immunology
Minimally Invasive Surgery

Background:

Known nickel hypersensitivity is a contraindication for intratubal microinsert placement in the US.
This case highlights the potential for developing nickel hypersensitivity to these devices post-placement.

Observation:

A young woman experienced an allergic reaction subsequent to the placement of intratubal microinserts.
Nickel hypersensitivity was definitively diagnosed via skin patch testing.

Findings:

The patient's allergic symptoms resolved after hysteroscopic removal of the microinserts.
This case confirms that intratubal microinserts can elicit nickel hypersensitivity.

Implications:

Patients experiencing allergic reactions post-hysteroscopic sterilization should be referred for allergy specialist evaluation.
Confirmed nickel hypersensitivity necessitates removal of intratubal microinserts, potentially via hysteroscopy.