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Updated: Jun 5, 2026

Microinjectrode System for Combined Drug Infusion and Electrophysiology
Published on: November 13, 2019
Nickel hypersensitivity associated with an intratubal microinsert system
Zain Al-Safi1, Valerie I Shavell, Lon E Katz
1From the Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan; and the Detroit Medical Center, Detroit, Michigan.
Background:
Although known nickel hypersensitivity is a contraindication to intratubal microinsert placement in the United States, this case demonstrates that nickel hypersensitivity to intratubal microinserts can occur.
Case:
A young woman developed an allergic reaction after placement of intratubal microinserts. Nickel hypersensitivity was confirmed with skin patch testing. The microinserts were removed hysteroscopically, and the patient improved.
Conclusion:
If a patient experiences symptoms of an allergic reaction after hysteroscopic sterilization, referral to an allergy specialist is recommended. If nickel hypersensitivity is confirmed, the microinserts should be removed; this may be performed under hysteroscopic guidance.
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