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Related Concept Videos

Pedigree Analysis01:35

Pedigree Analysis

Overview
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Inheritance01:25

Inheritance

Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype traits...

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Related Experiment Video

Updated: Jun 5, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Multifactorial inheritance in man.

S A Farrell

    Canadian Family Physician Medecin De Famille Canadien
    |January 22, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Multifactorial inheritance, involving genetic and environmental factors, underlies many common medical disorders. Understanding this complex inheritance is crucial for effective patient care in conditions like spina bifida and type-II diabetes mellitus.

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    Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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    Last Updated: Jun 5, 2026

    A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
    08:22

    A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

    Published on: December 1, 2017

    Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
    09:37

    Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

    Published on: August 15, 2019

    Area of Science:

    • Genetics
    • Medicine
    • Public Health

    Background:

    • Many common medical disorders result from a combination of genetic predisposition and environmental influences.
    • Multifactorial inheritance describes conditions influenced by multiple genes and non-genetic factors.
    • Conditions such as spina bifida and type-II diabetes mellitus exemplify multifactorial inheritance patterns.

    Purpose of the Study:

    • To explore the fundamental principles of multifactorial inheritance.
    • To illustrate the clinical relevance of multifactorial inheritance in common diseases.
    • To enhance understanding of how genetic and non-genetic factors interact in disease etiology.

    Main Methods:

    • Review of established genetic and epidemiological principles.
    • Clinical case examples of spina bifida and type-II diabetes mellitus.
    • Discussion of the interplay between genetic susceptibility and environmental triggers.

    Main Results:

    • Multifactorial inheritance is a significant contributor to the etiology of numerous prevalent diseases.
    • The interplay of genetic and environmental factors dictates individual risk and disease manifestation.
    • Understanding these interactions is key to developing targeted prevention and treatment strategies.

    Conclusions:

    • Multifactorial inheritance is a critical concept in modern medicine, impacting a wide range of disorders.
    • Clinical applications of understanding multifactorial inheritance can improve patient outcomes and healthcare.
    • Further research into specific gene-environment interactions is warranted for personalized medicine approaches.