Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Karyotyping

Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...

Karyotyping

Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...

FISH - Fluorescent In-situ Hybridization

FISH - Fluorescent In-situ Hybridization

Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

First Measurement of the Quadrupole Moment of the 2_{1}^{+} State in ^{110}Sn.

Physical review letters·2025

Same author

Identification of Prompt Proton Emission in N=Z-1 ^{61}Ga: Isospin Symmetry at the Limit of Nuclear Binding.

Physical review letters·2025

Same author

Modelling simultaneous detection of electrons and <math><mi>γ</mi></math> rays in-beam.

The European physical journal. A, Hadrons and nuclei·2025

Same author

Fine structure in the <math></math> decay of <math></math> Hg and <math></math> Au.

The European physical journal. A, Hadrons and nuclei·2025

Same author

Manifestation of relativistic effects in the chemical properties of nihonium and moscovium revealed by gas chromatography studies.

Frontiers in chemistry·2024

Same author

Observation of Single-Top-Quark Production in Association with a Photon Using the ATLAS Detector.

Physical review letters·2023

Same journal

Impact of virtual case conferences between primary care clinicians and an interdisciplinary chronic pain clinic.

Canadian family physician Medecin de famille canadien·2026

Same journal

Canadian family physician Medecin de famille canadien·2026

Same journal

Predictors of high-performing family medicine clinics: Prospective cohort study in Alberta.

Canadian family physician Medecin de famille canadien·2026

Same journal

Acetylsalicylic acid use for artial fibrillation and bleeding risk.

Canadian family physician Medecin de famille canadien·2026

Same journal

Clinical practice guidelines: Important tools to teach the art of medicine.

Canadian family physician Medecin de famille canadien·2026

Same journal

Paratonia in advanced dementia: Challenges and evidence-based interventions.

Canadian family physician Medecin de famille canadien·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Chromosome Preparation From Cultured Cells

Chromosome Preparation From Cultured Cells

Published on: January 28, 2014

Basic cytogenetics for office practice.

B Roland, D M Cox

Canadian Family Physician Medecin De Famille Canadien

|January 22, 2011

Summary

This summary is machine-generated.

Chromosome abnormalities cause various clinical issues. Cytogenetic analysis detects these numerical and structural changes, enabling accurate diagnosis, genetic counseling, and improved patient care for all ages.

More Related Videos

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease

Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease

Published on: February 3, 2012

Related Experiment Videos

Last Updated: Jun 5, 2026

Chromosome Preparation From Cultured Cells

Chromosome Preparation From Cultured Cells

Published on: January 28, 2014

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease

Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease

Published on: February 3, 2012

Area of Science:

Medical Genetics
Human Genetics
Clinical Cytogenetics

Background:

Clinical problems arise from alterations in the chromosome complement, ranging from common to rare conditions.
These numerical and structural chromosome abnormalities impact patients across all life stages.

Purpose of the Study:

To highlight the significance of cytogenetic analysis in diagnosing chromosome disorders.
To inform family physicians about the role of cytogenetic investigations in patient management.

Main Methods:

Detection of numerical and structural chromosome abnormalities.
Utilizing cell culture and analysis within a cytogenetics laboratory.
Defining the chromosome complement using standardized nomenclature.

Main Results:

Cytogenetic investigations readily detect chromosome abnormalities.
Diagnosis of chromosome disorders is achievable through laboratory analysis.

Conclusions:

Accurate diagnosis of chromosome disorders facilitates better patient counseling.
Identifying chromosomal abnormalities leads to improved patient care and management strategies.