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Tetrahymena Gene Expression Database (TGED): a resource of microarray data and co-expression analyses for Tetrahymena
Jie Xiong1, XingYi Lu, YuMing Lu
1Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.
Science China. Life Sciences
|January 22, 2011
Summary
The Tetrahymena Gene Expression Database (TGED) offers a user-friendly interface for exploring gene expression in the model organism Tetrahymena thermophila. This resource aids researchers in understanding fundamental cell and molecular biology through comprehensive expression data.
Area of Science:
- Eukaryotic molecular biology
- Genomics
- Bioinformatics
Background:
- Tetrahymena thermophila is a widely used model organism for eukaryotic research.
- Functional genomic analyses are crucial for understanding fundamental biological processes.
- Existing resources for Tetrahymena gene expression data were limited.
Purpose of the Study:
- To establish the first comprehensive gene expression database for Tetrahymena.
- To provide a user-friendly platform for accessing and analyzing gene expression data.
- To support functional genomic studies in Tetrahymena and other ciliates.
Main Methods:
- Development of a web-based database (TGED).
- Integration of microarray data across three key physiological states: growth, starvation, and conjugation.
- Implementation of search functionalities by Gene ID and Gene description.
Main Results:
- TGED provides access to gene expression profiles for Tetrahymena.
- Candidate co-expressed genes can be identified for any given gene.
- Standardized methods for sample preparation are documented.
Conclusions:
- TGED serves as a valuable resource for the Tetrahymena research community.
- The database facilitates deeper insights into eukaryotic gene regulation and function.
- TGED encourages data sharing and collaborative research in ciliate biology.
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