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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Anti-inflammatory flavonolignans from Hydnocarpus anthelminthica seeds
Jun-Feng Wang1, Ge-Fen Yin, Xiao-Jiang Zhou
1College of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.
Journal of Asian Natural Products Research
|January 22, 2011
Abstract:
A new flavonolignan, anthelminthicol A (1), together with four known compounds, was isolated from the EtOAc extracts of the seeds of Hydnocarpus anthelminthica. Their structures were elucidated using extensive spectroscopic techniques. Bioassay showed that compounds 3-5 could inhibit nitric oxide production in LPS-stimulated RAW 264.7 macrophage cell lines, with IC(50) values of 7.81, 9.38, and 10.55 μM, respectively.
