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Updated: Jun 5, 2026
09:39
Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
Published on: July 29, 2016
Functioning and disability in adults with myotonic dystrophy type 1.
Marie Kierkegaard1, Karin Harms-Ringdahl, Lotta Widén Holmqvist
1Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. marie.kierkegaard@karolinska.se
Disability and Rehabilitation
|January 25, 2011
Summary
Myotonic dystrophy type 1 (DM1) significantly impacts functioning and disability across disease stages. Early interventions focusing on manual dexterity and walking capacity can improve daily living and social participation for individuals with DM1.
Area of Science:
- Neurology
- Rehabilitation Medicine
- Clinical Research
Background:
- Myotonic dystrophy type 1 (DM1) is a progressive multisystem disorder.
- Understanding disease progression's impact on functioning is crucial for patient care.
Purpose of the Study:
- To describe functioning and disability in adults with DM1 across disease stages.
- To explore associations between manual dexterity, walking capacity, activities of daily living (ADL), and social participation.
Main Methods:
- Seventy individuals with DM1 were assessed using examinations, tests, and questionnaires.
- Disease progression was categorized using the muscular impairment rating scale.
Main Results:
- High prevalence of overweight, cardiac, respiratory, and fatigue issues (approx. 40%).
- Over 75% experienced muscle impairments and limitations in manual dexterity and walking.
- Significant differences in functioning were observed across disease progression stages, with proposed cut-off values for key measures.
Conclusions:
- Findings highlight the high burden of impairments, activity limitations, and participation restrictions in DM1.
- This data can inform clinical practice and health promotion strategies for DM1 patients.
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