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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

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Updated: Jun 5, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Long noncoding RNAs in cell biology.

Michael B Clark1, John S Mattick

  • 1Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road, St Lucia, QLD 4072, Australia.

Seminars in Cell & Developmental Biology
|January 25, 2011
PubMed
Summary
This summary is machine-generated.

Long non-protein-coding RNAs (lncRNAs) are dynamically expressed in animals, but their functions remain unclear. Research shows lncRNAs traffic to various subcellular locations, offering insights into cell biology and novel organelle components.

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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Related Experiment Videos

Last Updated: Jun 5, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Area of Science:

  • Molecular Biology
  • Genomics
  • Cell Biology

Background:

  • Whole genome transcriptomic analyses reveal numerous dynamically expressed long non-protein-coding RNAs (lncRNAs) in animals.
  • The functions of most identified lncRNAs are currently largely unknown.
  • lncRNAs, similar to messenger RNAs (mRNAs), are increasingly recognized for their potential roles in diverse cellular processes.

Purpose of the Study:

  • To summarize the evidence for the subcellular trafficking and localization of lncRNAs.
  • To highlight the potential of studying lncRNA distribution for understanding their functions.
  • To explore how lncRNA investigation can advance general cell biology knowledge.

Main Methods:

  • Review of existing literature on lncRNA expression and localization.
  • Analysis of transcriptomic data to identify dynamically expressed lncRNAs.
  • Summarization of experimental evidence regarding lncRNA subcellular distribution.

Main Results:

  • Growing evidence indicates lncRNAs are trafficked to and function in various subcellular locations.
  • Subcellular localization patterns suggest diverse roles for lncRNAs within the cell.
  • lncRNA distribution studies are beginning to reveal novel cellular structures and organelle components.

Conclusions:

  • Investigating the subcellular distribution of lncRNAs is crucial for elucidating their functions.
  • Understanding lncRNA localization can significantly expand knowledge of fundamental cell biology.
  • This research area holds potential for discovering previously unknown subcellular compartments and molecular constituents of organelles.