Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Pedigree Analysis01:35

Pedigree Analysis

Overview
Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Causes of Social Behavior III: Biological and Environmental Influences01:28

Causes of Social Behavior III: Biological and Environmental Influences

Social behavior is a complex phenomenon that arises from the interaction between biological predispositions and environmental influences. This intricate interplay shapes how individuals think, feel, and act in various social contexts. Understanding these mechanisms requires insights from psychology, neuroscience, genetics, and evolutionary theory.Environmental Influences on Social BehaviorEnvironmental factors, including temperature, odors, and visual stimuli, play a crucial role in shaping...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Virilization at puberty in adolescent girls may reveal a 46,XY disorder of sexual development.

Endocrine connections·2023
Same author

The orchestration of gene expression and the editing role of microRNA.

Journal of pediatric urology·2023
Same author

Comparative study of open, laparoscopic and endoscopic treatments of intermediate grade vesicoureteral reflux in children.

Surgical endoscopy·2022
Same author

[Environmental endocrine disruptors and fertility].

Gynecologie, obstetrique, fertilite & senologie·2021
Same author

Radiological and surgical management of bleeding pancreatic pseudocyst in a pediatric patient.

Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica·2021
Same author

COVID-19 and research in pediatric urology.

Journal of pediatric urology·2021
Same journal

Blood-Based MicroRNAs as Biomarkers of Insulin Resistance in Childhood Obesity: A Systematic Review and meta-analysis.

Molecular and cellular endocrinology·2026
Same journal

Female-specific metabolic genetic liability reveals a separable metabolic dimension of polycystic ovary syndrome.

Molecular and cellular endocrinology·2026
Same journal

The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.

Molecular and cellular endocrinology·2026
Same journal

G1 regulation of BK<sub>Ca</sub> channel leads to decreased migration of senescent pericytes and improved age-related hearing loss.

Molecular and cellular endocrinology·2026
Same journal

Maternal butyrate administration ameliorates fetal fatty liver and maternal metabolic alterations related to maternal obesity.

Molecular and cellular endocrinology·2026
Same journal

Retraction notice to " Steroid-induced oocyte maturation in Indian shad Tenualosa ilisha (Hamilton, 1822) is dependent on phosphatidylinositol 3 kinase but not MAP kinase activation" [Mol. Endocrinol. 390 (2014) 26-33].

Molecular and cellular endocrinology·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection
06:05

Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection

Published on: October 12, 2017

Hypospadias: interactions between environment and genetics.

N Kalfa1, P Philibert, L S Baskin

  • 1Service d'Hormonologie, Hôpital Lapeyronie, CHU de Montpellier et UM1, Montpellier, France.

Molecular and Cellular Endocrinology
|January 25, 2011
PubMed
Summary
This summary is machine-generated.

Hypospadias, a common congenital malformation, is linked to androgen issues but often unexplained. Recent research reviews genetic and environmental factors contributing to this complex condition.

More Related Videos

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System
03:49

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System

Published on: September 20, 2018

Related Experiment Videos

Last Updated: Jun 5, 2026

Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection
06:05

Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection

Published on: October 12, 2017

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System
03:49

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System

Published on: September 20, 2018

Area of Science:

  • Pediatric Urology
  • Developmental Biology
  • Genetics

Background:

  • Hypospadias is a frequent congenital malformation in 46,XY individuals.
  • It is considered a mild form of disorders of sex development (DSD).
  • The exact causes of hypospadias are not fully understood, with androgen pathway disruptions implicated in only a minority of cases.

Purpose of the Study:

  • To review recent advancements in understanding hypospadias etiology.
  • To explore the complex interplay between genetic and environmental factors in hypospadias development.
  • To highlight the heterogeneity of unexplained hypospadias cases.

Main Methods:

  • Literature review of recent studies on hypospadias.
  • Analysis of genetic factors, including gene mutations.
  • Discussion of potential environmental influences and gene-environment interactions.

Main Results:

  • While androgen synthesis or action defects can cause hypospadias, genetic mutations explain only a small fraction of cases.
  • The majority of hypospadias cases remain unexplained, suggesting significant etiological heterogeneity.
  • Evidence points to a multifactorial origin involving multiple genes and environmental exposures.

Conclusions:

  • Hypospadias etiology is complex and likely involves a combination of genetic predispositions and environmental triggers.
  • Further research is needed to elucidate the specific genetic and environmental factors contributing to unexplained hypospadias.
  • Understanding these interactions is crucial for potential future prevention or management strategies.