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Related Experiment Video

Updated: Jun 5, 2026

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
06:37

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Published on: October 20, 2010

Sentinel lymph node detection by an optical method using scattered photons.

Franklin Tellier, Rasata Ravelo, Hervé Simon

    Biomedical Optics Express
    |January 25, 2011
    PubMed
    Summary
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    This study introduces a novel near-infrared optical probe for sentinel lymph node detection. The probe significantly improves dye detection sensitivity, offering a 30-fold enhancement over visual methods.

    Area of Science:

    • Biomedical Optics
    • Medical Imaging
    • Surgical Navigation

    Background:

    • Sentinel lymph node biopsy is crucial for cancer staging.
    • Current detection methods for sentinel lymph nodes have limitations in sensitivity.
    • Patent Blue V dye is commonly used but has a high visual detection threshold.

    Purpose of the Study:

    • To develop and evaluate a new near-infrared optical probe for enhanced sentinel lymph node detection.
    • To improve the sensitivity threshold for detecting Patent Blue V dye.
    • To provide a more accurate method for identifying sentinel lymph nodes during surgery.

    Main Methods:

    • Utilized a two-wavelength near-infrared optical setup.
    • Employed modulated laser diodes and Fast Fourier Transform (FFT) signal analysis.

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    Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
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    Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

    Published on: March 8, 2013

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    Last Updated: Jun 5, 2026

    Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
    06:37

    Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

    Published on: October 20, 2010

    Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
    09:52

    Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

    Published on: March 8, 2013

  • Calculated relative Patent Blue V concentration from signal amplitudes.

    • Main Results:

    • Achieved a sensitivity threshold of 3.2 µmol/L for Patent Blue V dye detection.
    • Demonstrated a thirty-fold improvement in sensitivity compared to the visual threshold.
    • Validated the probe's performance using phantom models and small animal experiments.

    Conclusions:

    • The developed near-infrared optical probe offers significantly improved sensitivity for sentinel lymph node detection.
    • This technology has the potential to enhance surgical accuracy and patient outcomes in cancer staging.
    • The probe represents a promising advancement in optical imaging for surgical guidance.