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Endolymph pressure in Menière's disease
1Shea Clinic, Memphis, TN 38119.
Summary
This study measured endolymphatic pressure in Meniere's disease patients undergoing streptomycin perfusion. Elevated pressure correlated with negative summating potentials, decreasing after surgical shunting.
Area of Science:
- Otolaryngology
- Neurosurgery
- Neuroscience
Background:
- Meniere's disease is a disorder of the inner ear.
- Streptomycin perfusion/shunt is a surgical treatment for Meniere's disease.
- Endolymphatic pressure and electrocochleography are key diagnostic indicators.
Purpose of the Study:
- To investigate the relationship between endolymphatic pressure and electrocochleography findings in Meniere's disease.
- To evaluate the effect of streptomycin perfusion/shunt on endolymphatic pressure.
- To determine criteria for surgical intervention.
Main Methods:
- Exposure of the lateral semicircular duct via bone removal.
- Measurement of lateral semicircular duct pressure before and after streptomycin perfusion/shunt.
- Simultaneous recording of electrocochleography during pressure measurements.
Main Results:
- Endolymphatic pressure in Meniere's disease typically ranges from 2 to 3 mm of water.
- Higher pressures are observed in ears with large negative summating potentials.
- Pressure decreases and negative summating potentials normalize after surgical shunting.
Conclusions:
- Endolymphatic pressure is a significant factor in Meniere's disease pathophysiology.
- Streptomycin perfusion/shunt effectively reduces elevated endolymphatic pressure.
- Surgical shunting may not be indicated in cases with normal endolymphatic pressure and normal electrocochleography.