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Endolymph pressure in Menière's disease.

J J Shea1

  • 1Shea Clinic, Memphis, TN 38119.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|November 1, 1990
PubMed
Summary

This study measured endolymphatic pressure in Meniere's disease patients undergoing streptomycin perfusion. Elevated pressure correlated with negative summating potentials, decreasing after surgical shunting.

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Area of Science:

  • Otolaryngology
  • Neurosurgery
  • Neuroscience

Background:

  • Meniere's disease is a disorder of the inner ear.
  • Streptomycin perfusion/shunt is a surgical treatment for Meniere's disease.
  • Endolymphatic pressure and electrocochleography are key diagnostic indicators.

Purpose of the Study:

  • To investigate the relationship between endolymphatic pressure and electrocochleography findings in Meniere's disease.
  • To evaluate the effect of streptomycin perfusion/shunt on endolymphatic pressure.
  • To determine criteria for surgical intervention.

Main Methods:

  • Exposure of the lateral semicircular duct via bone removal.
  • Measurement of lateral semicircular duct pressure before and after streptomycin perfusion/shunt.
  • Simultaneous recording of electrocochleography during pressure measurements.

Main Results:

  • Endolymphatic pressure in Meniere's disease typically ranges from 2 to 3 mm of water.
  • Higher pressures are observed in ears with large negative summating potentials.
  • Pressure decreases and negative summating potentials normalize after surgical shunting.

Conclusions:

  • Endolymphatic pressure is a significant factor in Meniere's disease pathophysiology.
  • Streptomycin perfusion/shunt effectively reduces elevated endolymphatic pressure.
  • Surgical shunting may not be indicated in cases with normal endolymphatic pressure and normal electrocochleography.

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