Related Experiment Video

Updated: Jun 5, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
11:13

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Published on: June 9, 2023

Resveratrol and cellular mechanisms of cancer prevention

Yogeshwer Shukla1, Richa Singh

  • 1Indian Institute of Toxicology Research, Lucknow, India. yogeshwer_shukla@hotmail.com

Annals of the New York Academy of Sciences
|January 26, 2011
PubMed

Insights

Resveratrol, a natural polyphenol, shows promise as an anticancer agent by inducing apoptosis. Further research into its molecular mechanisms supports its potential as a future cancer chemopreventive and chemotherapeutic drug.

Area of Science:

  • Oncology
  • Natural Products Chemistry
  • Molecular Biology

Background:

  • The increasing need for novel cancer chemopreventive and chemotherapeutic agents.
  • Natural products, particularly flavonoids like resveratrol, are recognized for their potential health benefits.
  • Epidemiological studies link higher flavonoid intake to reduced cancer risk, with apoptosis induction being a key mechanism.

Purpose of the Study:

  • To explore the chemopreventive and chemotherapeutic potential of resveratrol.
  • To elucidate the molecular mechanisms underlying resveratrol's anticancer properties.
  • To advocate for resveratrol as a future anticancer drug.

Main Methods:

  • Review of preclinical findings on resveratrol's anticancer effects.
  • Focus on the molecular pathways targeted by resveratrol.
  • Analysis of existing scientific literature on resveratrol's biological activities.

Main Results:

  • Resveratrol exhibits pleiotropic health benefits, including antioxidant and anti-inflammatory activities.
  • Preclinical data suggest resveratrol is a potent natural agent against cancer.
  • Significant progress has been made in understanding how resveratrol targets cancer cells.

Conclusions:

  • Resveratrol demonstrates considerable potential as a chemopreventive and chemotherapeutic agent.
  • Its ability to induce apoptosis is crucial for its anticancer effects.
  • Resveratrol is a promising candidate for future cancer drug development.

More Related Videos

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...