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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

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Deafness: malaria as a forgotten cause.

S Z Zhao¹, I J Mackenzie

¹World Health Organization Collaborating Centre for Prevention of Deafness, Child & Reproductive Health, Liverpool School of Tropical Medicine, Liverpool, UK.

Annals of Tropical Paediatrics

|January 26, 2011

Summary

This summary is machine-generated.

Malaria, particularly falciparum malaria, may cause hearing loss. This hearing impairment in children could negatively impact education, necessitating further research into this association.

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Area of Science:

Infectious Diseases
Otolaryngology
Neurology

Background:

Ototoxicity from antimalarial drugs is a known cause of hearing loss.
The impact of the malaria parasite itself on hearing is poorly understood and largely anecdotal.
This review collates existing evidence on the association between malaria and hearing impairment.

Purpose of the Study:

To investigate the potential link between malaria infection and hearing loss.
To review existing literature on hearing impairment as a consequence of malaria.
To highlight the need for further research into this under-documented association.

Main Methods:

Systematic literature searches were conducted using Ovid Medline.
Searches included terms for 'malaria,' 'hearing loss,' 'hearing impairment,' 'deafness,' 'cerebral malaria,' and neurological sequelae.
Relevant articles were identified and individually studied for their findings.

Main Results:

Malaria has been rarely implicated as a cause of hearing loss, with limited investigation.
Studies on neurological sequelae of cerebral malaria noted hearing impairments in some cases, without distinguishing cause.
Some antimalarial drug trials observed unexplained hearing loss that resolved after parasite elimination.

Conclusions:

The *falciparum* malaria parasite is suggested as a potential cause of hearing loss.
Given malaria's high prevalence, even a small rate of hearing impairment can have significant detrimental effects on children's education.
Further investigation into the clinical and pathophysiological implications of malaria-associated hearing loss is warranted.