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Related Experiment Video

Updated: Jun 5, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Rhabdomyosarcoma in 8 horses.

W L Castleman¹, D E Toplon, C K Clark

¹Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, PO Box 110880, Gainesville, FL 32611-0880, USA. castlemanw@ufl.edu

Veterinary Pathology

|January 26, 2011

Summary

This study details eight equine rhabdomyosarcoma cases, finding smaller tumors (<10 cm) treatable with surgery or radiation, while larger ones often proved inoperable. Early detection and treatment are crucial for better outcomes in horses.

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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

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Published on: January 13, 2023

Area of Science:

Veterinary Pathology
Equine Oncology

Background:

Rhabdomyosarcoma, a malignant tumor of muscle tissue, can occur in horses.
Understanding the presentation and prognosis of equine rhabdomyosarcoma is essential for diagnosis and treatment.

Observation:

Eight cases of equine rhabdomyosarcoma were analyzed, with primary sites including the head, abdominal wall, shoulder, and heart.
Tumor size significantly impacted treatment outcomes: smaller tumors (<10 cm) showed no recurrence after surgical excision or radiation.
Larger tumors (>10 cm) in the abdominal wall and shoulder were inoperable, leading to euthanasia.

Findings:

The majority of tumors were classified as embryonal rhabdomyosarcoma, with one pleomorphic case identified.
Common locations for equine rhabdomyosarcoma across this and previous studies include limb muscles and the tongue.
Metastasis was not observed in the current study's cases, contrasting with previous reports.

Implications:

Tumor size is a critical prognostic factor in equine rhabdomyosarcoma.
Surgical excision and radiation therapy are effective for smaller rhabdomyosarcomas, offering a positive prognosis.
Further research into equine rhabdomyosarcoma, particularly regarding metastasis and treatment of larger tumors, is warranted.