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Tc99m-renal imaging agent--the preparation and comparative clinical evaluation
M Jehangir1, A Wiqar, M Safdar
1Pakistan Institute of Nuclear Science and Technology, Islamabad.
JPMA. the Journal of the Pakistan Medical Association
|August 1, 1990
Summary
A locally prepared kit for Technetium-99m Diethylenetriaminepenta Acetic Acid (Tc99m DTPA) renal imaging demonstrated high labeling efficiency and stability. This development offers a comparable alternative to imported agents for various kidney function assessments.
Area of Science:
- Nuclear Medicine
- Radiopharmaceutical Chemistry
- Nephrology
Background:
- Radionuclide Tc99m DTPA (Diethylenetriaminepenta Acetic Acid) renal imaging is crucial for evaluating glomerular filtration rate (GFR), renal transit times, and diagnosing conditions like acute tubular necrosis (ATN) and transplant rejection.
- Current reliance on imported Tc99m DTPA kits necessitates local preparation for improved accessibility and cost-effectiveness.
Purpose of the Study:
- To develop and evaluate a locally prepared DTPA kit for Tc99m labeling.
- To assess the labeling efficiency, in vitro, and in vivo stability of the Tc99m DTPA preparation.
- To compare the efficacy of the locally prepared agent with imported renal imaging agents.
Main Methods:
- Preparation of a DTPA kit at PINSTECH.
- Evaluation of labeling efficiency using Tc99m pertechnetate.
- Assessment of in vitro stability (hydrolyzed Tc99m fraction) and in vivo stability through clinical trials.
- Comparison of results with imported Renal imaging (pentetate-II Technetium 99m) agents.
Main Results:
- The locally prepared Tc99m DTPA kit achieved a labeling efficiency exceeding 99%.
- The fraction of hydrolyzed Tc99m was less than 1%, indicating high radiochemical purity.
- In vitro and in vivo stability studies demonstrated comparable results to imported agents.
- Clinical trials showed no artifacts on scintigraphic images, confirming diagnostic quality.
Conclusions:
- The locally developed Tc99m DTPA kit is a viable and effective agent for renal imaging.
- The kit exhibits excellent labeling efficiency, stability, and diagnostic quality, comparable to imported radiopharmaceuticals.
- This local preparation can potentially reduce costs and improve the availability of Tc99m DTPA for renal function assessments.